Ion Trap Tutorial and Resource Links

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Ion Trap Reviews and Tutorials

  The Whys and Wherefores of Quadrupole Ion Trap Mass Spectrometry.  Karen R. Jonscher and John R. Yates, III University of Washington at Seattle.  The best starting place to learn about traps.

   Trap information  Here are a few words from Brian Tissue's The Chemistry Hyper Media Project

   Ion trap animations from Thermo Fisher Scientific

Ion Trap Distributors and Company Supplied Trap Information


Agilent LC/MSD 3D Ion Trap

     LC/MSD Trap XCT Plus

     LC/MSD Trap XCT

     LC/MSD Trap SL

     LC/MSD Trap VL

Applied Biosystems 2D Ion Traps

     4000 Q TRAP� LC/MS/MS System

     Q TRAP� LC/MS/MS System

  Brucker Daltonics 3D Ion Traps





  Thermo Scientific LC/MS Ion Trap Product Portfolio  

  More references:

Jonscher KR, Yates JR 3rd. The quadrupole ion trap mass spectrometer--a small solution to a big challenge. Anal Biochem. 1997 Jan 1;244(1):1-15. Review.  PMID: 9025900; UI: 97178507

Jonscher KR, Yates JR 3rd. Matrix-assisted laser desorption ionization/quadrupole ion trap mass spectrometry of peptides. Application to the localization of phosphorylation sites on the P protein from Sendai virus. J Biol Chem. 1997 Jan 17;272(3):1735-41.  PMID: 8999854; UI: 97153133

Jonscher KR, Yates JR 3rd. Mixture analysis using a quadrupole mass filter/quadrupole ion trap mass spectrometer. Anal Chem. 1996 Feb 15;68(4):659-67. PMID: 8999740; UI: 97145979

McLuckey SA, Van Berkel GJ, Goeringer DE, Glish GL. Ion trap mass spectrometry. Using high-pressure ionization. Anal Chem. 1994 Jul 15;66(14):737A-743A. Review. PMID: 8080116; UI: 94361286

  Metabolite Studies Performed Using Ion Traps (Journal Articles)

New (Thank you Patrick Dansette for these suggestions)

  1. Jushchyshyn MI, Kent UM, Hollenberg PF., The mechanism-based inactivation of human cytochrome p450 2B6 by phencyclidine. Drug Metab Dispos. 2003 Jan;31(1):46-52. PMID: 12485952 

  2. Blobaum AL, Kent UM, Alworth WL, Hollenberg PF., Mechanism-Based Inactivation of Cytochromes P450 2E1 and 2E1 T303A by tert-Butyl Acetylenes: Characterization of Reactive Intermediate Adducts to the Heme and Apoprotein. Chem Res Toxicol. 2002 Dec;15(12):1561-71. PMID: 12482238 

  3. Lin HL, Kent UM, Hollenberg PF., Links Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein. 
    J Pharmacol Exp Ther. 2002 Apr;301(1):160-7. PMID: 11907170 

  4. Kent UM, Mills DE, Rajnarayanan RV, Alworth WL, Hollenberg PF., Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 
    and 2B6 and identification of metabolites. J Pharmacol Exp Ther. 2002 Feb;300(2):549-58. PMID: 11805216 

  5. Kent UM, Roberts-Kirchhoff ES, Moon N, Dunham WR, Hollenberg PF., Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1. Biochemistry. 2001 Jun 19;40(24):7253-61. PMID: 11401573

  6. Goosen TC, Kent UM, Brand L, Hollenberg PF. ,  Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables. Chem Res Toxicol. 2000 Dec;13(12):1349-59. PMID: 11123978

  7. Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metab Dispos. 2000 Aug;28(8):905-11. PMID: 10901699

  8. Yanev SG, Kent UM, Roberts ES, Ballou DP, Hollenberg PF. Mechanistic studies of cytochrome P450 2B1 inactivation by xanthates. Arch Biochem Biophys. 2000 Jun 1;378(1):157-66. PMID: 10871056

  9. Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF.  Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry. Chem Res Toxicol. 2000 Apr;13(4):262-70.  PMID: 10775326

  10. Liminga M, Oliw E. Qualitative and quantitative analysis of lipoxygenase products in bovine corneal epithelium by liquid chromatography-mass spectrometry with an ion trap. Lipids. 2000 Feb;35(2):225-32. PMID: 10757554; UI: 20218480 

  11. Montesissa C, Anfossi P, Biancotto G, Angeletti R. In vitro metabolism of clenbuterol and bromobuterol by pig liver microsomes. Xenobiotica. 1998 Nov;28(11):1049-60. PMID: 9879637; UI: 99094246

  12. Marzilli LA, Wang D, Kobertz WR, Essigmann JM, Vouros P. Mass spectral identification and positional mapping of aflatoxin B1-guanine adducts in oligonucleotides. J Am Soc Mass Spectrom. 1998 Jul;9(7):676-82.
    PMID: 9879377; UI: 99095450

  13. Prokai L, Zharikova AD. Identification of synaptic metabolites of dynorphin A (1-8) by electrospray ionization and tandem mass spectrometry. Rapid Commun Mass Spectrom. 1998;12(22):1796-800. PMID: 9853388; UI: 99070500

  14. Oliw EH, Su C, Skogstrom T, Benthin G. Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn. Lipids. 1998 Sep;33(9):843-52. PMID: 9778131; UI: 98449580

  15. Coldham NG, Dave M, Sauer MJ. Analysis of di-n-butylphthalate biotransformation in cattle by liquid chromatography/ion trap mass spectrometry/mass spectrometry. J Mass Spectrom. 1998 Sep;33(9):803-10. PMID: 9768498; UI: 98441617

  16. Tiller PR, Land AP, Jardine I, Murphy DM, Sozio R, Ayrton A, Schaefer WH. Application of liquid chromatography-mass spectrometry(n) analyses to the characterization of novel glyburide metabolites formed in vitro. J Chromatogr A. 1998 Jan 23;794(1-2):15-25. PMID: 9491553; UI: 98152253

  17. Shockcor JP, Unger SE, Wilson ID, Foxall PJ, Nicholson JK, Lindon JC. Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine. Anal Chem. 1996 Dec 15;68(24):4431-5. PMID: 8972626; UI: 97127926


If you have additional ion trap references please e-mail them to  


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