FOR IMMEDIATE RELEASE
Chromatography and Mass Spectrometry
Media Contact Information: Secondary Contact Information:
Name: Laura Browne/Charlotte Culley Stephanie Kubina
Phone: +44 1477 539539 +1 (408) 965-6022
Email: thermo@scottpr.com stephanie.kubina@thermofisher.com
Website: www.scottpr.com
Thermo Fisher Scientific Launches MetWorks™
1.1.0 Metabolite Identification Software
SAN DIEGO, Calif., (November 13, 2007) – Thermo Fisher
Scientific Inc., the world leader in serving science, today
launched MetWorks™ 1.1.0, an updated version of its proven
metabolite identification software. Thermo Scientific Metworks™
1.1.0 software facilitates automated acquisition, processing and
reporting of LC/MSn data in support of biotransformation
studies. MetWorks software is compatible with all Thermo
Scientific mass spectrometers capable of performing MS/MS and
MSn fragmentation. In addition, MetWorks allows high resolution
accurate mass data from the Thermo Scientific LTQ Orbitrap™ and
LTQ FT™ instruments to be fully leveraged.
MetWorks™ 1.1.0 software features enhanced tools that facilitate
distinguishing xenobiotic components from endogenous biological
matrix interferences in LC/MSn chromatograms and spectra. Key
improvements to the software include:
- Automatic generation of a Data-Dependent Parent Mass
Table (DDPT)
- Component filtering to exclude duplicates
originating from adducts and isotopic contributions
- Flexibility to apply up to six multiple mass defect
filters (MMDF’s), which are based on high-resolution,
exact mass and mass deficiencies of the parent-drug and
its putative metabolites. Chromatograms and spectra
filtered using MMDF’s contain fewer endogenous compounds
and excipient materials, thereby reducing the manual
intervention of eliminating false positives from the
results. Isotopic spectral pattern recognition
techniques, as well as MSn spectral correlation
procedures are used to identify common product ions and
mass shifts related to specific fragment neutral losses
- The structure column in the MetView™ table can be
used to attach a molecular structure drawing (.mol file)
to a potential putative candidate
Integration of Mass Frontier™ predictive fragmentation software
within the MetWorks™ 1.1.0 workflow process has drastically
improved the assessment for automated metabolite identification
studies. Mass Frontier™ predictive fragmentation tools
significantly decrease the time researchers require to
confidently identify and generate lists of drug metabolites.
MetWorks™ 1.1.0 collates and converts this information,
including calculated elemental formulae, chemical structures and
chromatograms into easy-to-read reports. In addition, the
software supports storage of user-generated mass spectral
libraries.
This powerful and flexible data-mining tool for small molecules
will be demonstrated in a new, pre-recorded webinar. Entitled
“MetWorks™ 1.1.0 Software for the Confident Analysis of Putative
Biotransformation Data”, the webinar is available for download
from
www.thermo.com/mseminar.
For more information about Thermo Scientific MetWorks™ 1.1.0
Software, please call +1 800-532-4752, e-mail analyze@thermofisher.com
or visit www.thermo.com/metabolism.
Mass Frontier™ is a trademark of HighChem, Ltd.
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Thermo Scientific is part of Thermo Fisher Scientific, the world
leader in serving science.
About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in
serving science, enabling our customers to make the world
healthier, cleaner and safer. With an annual revenue rate of
more than $9 billion, we employ 30,000 people and serve over
350,000 customers within pharmaceutical and biotech companies,
hospitals and clinical diagnostic labs, universities, research
institutions and government agencies, as well as environmental
and industrial process control settings. Serving customers
through two premier brands, Thermo Scientific and Fisher
Scientific, we help solve analytical challenges from routine
testing to complex research and discovery. Thermo Scientific
offers customers a complete range of high-end analytical
instruments as well as laboratory equipment, software, services,
consumables and reagents to enable integrated laboratory
workflow solutions. Fisher Scientific provides a complete
portfolio of laboratory equipment, chemicals, supplies and
services used in healthcare, scientific research, safety and
education. Together, we offer the most convenient purchasing
options to customers and continuously advance our technologies
to accelerate the pace of scientific discovery, enhance value
for customers and fuel growth for shareholders and employees
alike. Visit www.thermofisher.com.
For further press information please contact: Laura Browne, The
Scott Partnership. 1 Whiteside, Station Road, Holmes Chapel,
Cheshire CW4 8AA UK Tel: +44 1477 539539 Fax: +44 1477 539540
Email: thermo@scottpr.com